Certain Toxic Effects Higher With Newer Prostate Cancer Therapies
Second-generation anti-androgens (AAs) for the treatment of prostate cancer are associated with an increased risk of cognitive and functional toxic effects, according to results from a systematic review and meta-analysis. Across 12 randomized trials involving over 13,000 patients, increased risks of cognitive toxic effects (risk ratio [RR] 2.10, 95% CI 1.30-3.38, P=0.002) and fatigue (RR […]
Here’s Why You Need To Be Extra Careful Eating This Popular Seafood
Oscar Wong via Getty Images There are some risks associated with eating raw oysters. In a viral TikTok video with 2.2 million views, TikTok user @malamamaofficial opens a $1 Whole Foods bag of raw oysters, revealing a pea crab in one of the shells. “This is why it’s $1,” the TikTok user says as she […]
Weekly Exercise May Help Reduce Flu, Pneumonia Deaths
Meeting weekly exercise guidelines was associated with lower pneumonia and influenza mortality, a longitudinal study of U.S. adults showed. People who met both aerobic physical activity and muscle-strengthening activity guidelines had a 48% lower adjusted risk for pneumonia and influenza death over a median of 9.2 years of follow-up compared with those who met neither […]
Sleep Apnea Patients Prone to Higher Long COVID Risk
Preexisting obstructive sleep apnea (OSA) was associated with up to a 75% increased risk of long COVID in adults, an analysis from the NIH RECOVER collaboration found. Unadjusted odds of post-acute sequelae of SARS-CoV-2 (PASC) were significantly higher for adult and pediatric patients with a prepandemic OSA diagnosis, according to electronic health record (EHR) data […]
Scoliosis Cramps Heart Function in Adulthood
Scoliosis was associated with altered cardiac function and an increase in cardiac events among adults in the U.K. Biobank, researchers found. Compared with peers without scoliosis, those with such sideways spinal curvature exhibited a greater lifetime risk of major adverse cardiovascular events (MACE; HR 1.45, P<0.001), driven by heart failure (HR 1.58, P<0.001) and atrial […]
Higher BMI Tied to Other Severe Respiratory Infections Too
A higher body mass index (BMI) was associated with increased risks for hospitalization and death due to COVID-19 and other respiratory infections as well, according to a study using data from the U.K. Biobank. After a mean follow-up of 11.8 years, the hazard ratios per 10-unit higher BMI was 2.26 (95% CI 2.05-2.49) for severe […]
FDA Advisors Endorse Rexulti for Agitation in Alzheimer’s Dementia
FDA advisors voted in favor of brexpiprazole (Rexulti) for treating agitation associated with Alzheimer’s dementia (AAD), despite increased mortality risk. By a vote of 9-1 on Friday, members of the agency’s Psychopharmacologic Drugs Advisory Committee (PDAC) and the Peripheral and Central Nervous System Drugs Advisory Committee (PCNS) said the data presented by the drug’s sponsors, […]
Bariatric Surgery May Eliminate Obesity-Related Breast Cancer Risk
Bariatric surgery for women with obesity was associated with a reduction in breast cancer risk that reached levels seen among those with a normal body mass index (BMI), researchers have found. In their retrospective study of almost 70,000 women, an increased risk for incident breast cancer was observed in women who did not undergo bariatric […]
Dementia Risk May Rise as Air Quality Worsens
Exposure to particulate matter smaller than 2.5 microns in diameter (PM2.5) was associated with increased risk of dementia, a meta-analysis suggested. Across 14 studies that assessed PM2.5, the overall risk of dementia rose by 4% (HR 1.04, 95% CI 0.99-1.09) for every 2 μg/m3 increase in average annual PM2.5 concentration, according to Marc Weisskopf, PhD, […]
What Drives Alzheimer’s in Women?
Female sex, early age at menopause, and hormone therapy use each were associated with higher regional tau in cognitively normal people with elevated beta-amyloid, cross-sectional PET data showed. The highest levels of tau were seen in hormone therapy users who had a delay of more than 5 years between menopause onset and the start of […]