No Aspirin Needed After LVAD, ARIES-HM3 Trial Says
PHILADELPHIA — Dropping aspirin from the antithrombotic regimen after HeartMate 3 left ventricular assist device (LVAD) implantation appeared safer than the usual combination approach in the ARIES-HM3 trial. Atop warfarin or other vitamin K antagonist therapy, placebo was noninferior to low-dose aspirin for the primary composite endpoint of survival free of stroke, pump thrombosis, major […]
Daily Low-Dose Aspirin Upped Incidence of Anemia in Older Adults
Daily low-dose aspirin increased incident anemia among otherwise healthy older adults, a secondary analysis of the randomized ASPREE trial showed. Over a median of 4.7 years, the incidence of anemia was 51.2 events per 1,000 person-years in the aspirin group compared with 42.9 events per 1,000 person-years in the placebo group (HR 1.20, 95% CI […]
Early DAPT Improves Outcomes for Strokes With No Other Tx Options
DALLAS — Adding tirofiban (Aggrastat) to aspirin for dual antiplatelet therapy (DAPT) within 24 hours of acute ischemic stroke improved outcomes for patients who weren’t candidates for thrombolytic or endovascular treatment, according to a phase III trial from China. The combination of the glycoprotein IIb/IIIa inhibitor with aspirin shifted modified Rankin Scale (mRS) scores in […]
Extra Pounds May Blunt Benefit of Aspirin in Advanced Colorectal Cancer
The association between aspirin use following an advanced colorectal cancer diagnosis and better survival was only significant among patients with a normal body mass index (BMI) prediagnosis, a cross-sectional study found. In the large single-center analysis of patients diagnosed with stage IV disease, those with prediagnosis obesity had a higher risk for death compared with […]
Pathogens Head for Surgical Helmets During Orthopedic Surgeries
Bacterial colonization of surgical helmets, a prophylactic aspirin regimen for venous thromboembolism (VTE), and the value of virtual visits in pediatric orthopedics were examined in several studies at the American Academy of Orthopaedic Surgeons meeting. Pathogens and Surgical Helmets Nearly three-fourths of a sample of surgical helmets and surgeons’ foreheads swabbed after a day’s worth […]