E-Cigs in Early Adolescence Tied to Heavier Smoking Later On
Use of electronic cigarettes during early adolescence appeared to increase the odds of any smoking and more frequent tobacco cigarette use in later adolescence, according to longitudinal data from two large-scale cohorts in the U.K. and U.S. Among youths who began smoking before age 15, the odds of later adolescent smoking were significantly higher for […]
Heart Failure’s Obesity Paradox Falls Apart on Further Inspection
For the heart failure population, BMI obesity no longer appeared to hold counterintuitive protective effects after comprehensive adjustment for natriuretic peptides and other prognostic variables in a post hoc analysis of PARADIGM. Eliminating this so-called “obesity paradox,” researchers found that study participants with the highest BMIs actually had excess combined heart failure hospitalizations and cardiovascular […]
‘Ted Lasso’ Star Jason Sudeikis Talks Mental Health At White House
The stars of Apple TV+’s “Ted Lasso” appeared at the White House on Monday to discuss the importance of mental health. “No matter who you are, no matter where you live, no matter who you voted for,” we all know someone who has “struggled, that’s felt isolated, that’s felt anxious, that has felt alone,” said […]
Cardiac Arrest Growing More Common in the Delivery Room?
Cardiac arrest during labor and delivery appeared more common than previously seen — particularly for older, Black, and low-income pregnant patients — but with better survival rates, according to a national study. Among women admitted for delivery in the National Inpatient Sample (NIS) from 2017 to 2019, cardiac arrest occurred in about one in 9,000 […]
Opinion | Emergency Doctors Are Ill Prepared to Handle Psychiatric Emergencies
More than four decades ago, an article appeared in the American Journal of Psychiatry defining the subspecialty of emergency psychiatry (EP). Since those early days, despite some research and consolidation into a new association complementing emergency medicine (EM), the impact on meaningful access to, integration with, and quality of care for psychiatric emergencies has been […]
Sutezolid With 3-Drug Combo Appears Safe and Effective in Multidrug-Resistant TB
SEATTLE — Adding the oxazolidinone antibiotic sutezolid to a three-drug combination appeared to be safe and effective for people with multidrug-resistant tuberculosis (TB), according to a dose-finding phase II study. Across five treatment arms that included four different doses of sutezolid with bedaquiline, delamanid, and moxifloxacin at standard doses, there was a similar increase in […]
Weight Loss Advice From GPs Falls Flat for Patients With Obesity
Weight loss advice given by general practitioners (GPs) to patients with obesity appeared to be lacking, one U.K.-based qualitative study suggested. In an analysis of 159 audio recordings of patient consultations from the Brief Interventions for Weight Loss trial, the most common advice was diet and exercise, typically following an “eat less and do more” […]
Sequential Gemcitabine/Docetaxel Promising in NMIBC After BCG Relapse
SAN DIEGO — The use of sequential intravesical gemcitabine and docetaxel appeared effective and well tolerated in patients with high-risk non-muscle invasive bladder cancer (NMIBC) following the failure of bacillus Calmette-Guérin (BCG) therapy, a retrospective study showed. At a median follow-up of 18 months, the 6-, 12-, and 24-month high-grade recurrence-free survival (RFS) rates among […]
More Anti-Lockdown Protests In China Triggered By Deadly Fire
TAIPEI, Taiwan (AP) — Protests against China’s restrictive COVID-19 measures appeared to roil in a number of cities Saturday night, in displays of public defiance fanned by anger over a deadly fire in the western Xinjiang region. Many protests could not be immediately confirmed, but in Shanghai, police used pepper spray to stop around 300 […]
Novel BTK Inhibitor Looks Good for Sjogren’s Syndrome
PHILADELPHIA — Remibrutinib, an investigational Bruton’s tyrosine kinase (BTK) inhibitor, appeared effective in reducing signs of Sjogren’s syndrome in a randomized, placebo-controlled trial. Scores on the EULAR Sjogren’s Syndrome Activity Index (ESSDAI), a comprehensive measure of Sjogren’s severity, fell by 2.86 points with the oral drug relative to placebo during the 24-week trial, according to […]