Topical Gel Soothes Skin Rash for CRC Patients on EGFR Inhibitors
The use of an investigational topical BRAF-inhibiting gel appeared to be effective in treating acneiform rash in patients with advanced colorectal cancer who were treated with an epidermal growth factor receptor (EGFR)-targeted drug, a randomized phase II trial showed. The 39 patients randomly assigned to receive a high-dose 0.1% formulation of LUT014 gel were twice […]
Do GLP-1 Drugs Pose a Risk to Lung Transplant Recipients?
People taking GLP-1 receptor agonists appeared to be at elevated risk of rejection episodes after lung transplantation, a small, single-center cohort study suggested. In a retrospective review of 301 consecutive lung transplants, the 34 lung recipients taking a GLP-1 drug for diabetes or obesity early in their post-transplant course had 15.19-fold (95% CI 2.08-23.55, P<0.05) […]
Space Flights Provoke Tension Headaches, Migraine
Space flight appeared to provoke headaches in healthy astronauts, a prospective study showed. Of 24 astronauts who participated in long-haul space flights — ones that lasted at least 10 days — 91.7% experienced one or more headaches during a total of 3,596 space days, reported Willebrordus P. J. van Oosterhout, MD, PhD, of Leiden University […]
Breastfeeding While Taking MS Monoclonal Antibody Drugs Appears Safe
Exposure to multiple sclerosis (MS) monoclonal antibody treatment during breastfeeding appeared to have no negative effect on the early development or health of infants, registry data in Germany showed. Over the first 3 years of follow-up, no links emerged between exposure to monoclonal antibody drugs and annual hospitalization (rate ratio [RR] 1.23, P=0.473), annual systemic […]
Monthly ART Injections Top Pills for HIV Patients With Adherence Problems
Long-acting cabotegravir/rilpivirine (Cabenuva; CAB/RPV-LA) appeared superior to daily oral antiretroviral therapy (ART) in maintaining viral load suppression for people living with HIV who have trouble adhering to oral ART, according to an interim analysis of a phase III trial. At 52 weeks, numerically fewer patients assigned to monthly injections of CAB/RPV-LA experienced regimen failure — […]
Long COVID May Be Difficult to Identify in MS
WEST PALM BEACH, Fla. – People with multiple sclerosis (MS) appeared to have a low risk of developing long COVID, but lingering complaints after SARS-CoV-2 infection were difficult to untangle from MS symptoms, registry analyses showed. In studies presented at the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum, Robert Fox, MD, […]
Novel Oral Antibiotic Effective Against Uncomplicated UTIs
Gepotidacin — a first-in-class oral antibiotic — appeared effective and safe for the treatment of uncomplicated urinary tract infections (UTIs) in a pair of large, phase III non-inferiority studies. In the two trials — EAGLE-2 and EAGLE-3 — the therapy was shown to be noninferior to nitrofurantoin, an antibiotic commonly used as a first-line therapy […]
Alzheimer’s May Be Transmissible in Rare Circumstances
Alzheimer’s disease appeared to be transmissible under rare conditions, according to new research. Five patients treated with human growth hormone from cadaveric pituitary glands when they were children subsequently developed early dementia or biomarker changes consistent with Alzheimer’s disease, reported John Collinge, MD, of University College London in England, and co-authors in Nature Medicine. Four […]
Michael Strahan’s Daughter Isabella Diagnosed With Brain Tumor
LOADINGERROR LOADING Michael Strahan and his daughter, Isabella Strahan, appeared on “Good Morning America” Thursday to share her brain tumor diagnosis. Isabella Strahan was diagnosed with a type of malignant brain tumor known as medulloblastoma last October after starting to experience serious headaches about a month into her first semester at the University of Southern […]
Common Headaches May Be Pains in the Neck
CHICAGO — Inflammation and edema of the trapezius muscles appeared linked to tension and migraine headaches, a small prospective cohort study found. Patients with mixed-type tension and migraine headaches demonstrated the highest muscle T2 MRI values (31.4 ms on the right and left sides), and the average value was significantly higher compared to those with […]