Anti-Androgens Can Be Used for PCOS When Oral Contraceptives Can’t
Anti-androgens may be beneficial for managing certain hyperandrogenism-related symptoms of polycystic ovary syndrome (PCOS) in cases where combined oral contraceptive pills are contraindicated, poorly tolerated, or ineffective, according to the first systematic review and meta-analysis on the subject. Using data from 13 studies including a total of 961 patients, combination treatment with antiandrogens, metformin, and […]
Certain Toxic Effects Higher With Newer Prostate Cancer Therapies
Second-generation anti-androgens (AAs) for the treatment of prostate cancer are associated with an increased risk of cognitive and functional toxic effects, according to results from a systematic review and meta-analysis. Across 12 randomized trials involving over 13,000 patients, increased risks of cognitive toxic effects (risk ratio [RR] 2.10, 95% CI 1.30-3.38, P=0.002) and fatigue (RR […]