Novel Combination Boosts Survival in Unresectable Liver Cancer
The PD-1 inhibitor camrelizumab combined with the VEGFR2-targeted inhibitor rivoceranib (also known as apatinib) significantly improved survival compared with sorafenib (Nexavar) alone for the treatment of patients with unresectable hepatocellular carcinoma (HCC), a randomized phase III trial showed. At a median follow-up of 7.8 months, the median progression-free survival was 5.6 months with the two […]
Pre-Existing Depression, Anxiety Tied to Worse DLBCL Prognosis
Patients with diffuse large B-cell lymphoma (DLBCL) who also had pre-existing depression, anxiety, or both had a worse prognosis than those without these pre-existing mental health conditions, according to results from a population-based study. Among over 13,000 patients at a median follow-up of 2 years, the 5-year overall survival (OS) rate was 27% for patients […]
Full-On Reversal of Cardiac Amyloidosis Possible With Antibodies
It is possible for transthyretin amyloid cardiomyopathy (ATTR-CM, also called cardiac ATTR amyloidosis) to be reversed with antibody treatment, as suggested by rare cases of patients who had their ATTR-related heart failure resolve spontaneously, with cardiac structure and function restored to almost normal. In a small case series, three men (ages 68, 82, and 76) […]
Does Cold Plunging Actually Do Anything Or Is It B.S.?
Illustration:Jianan Liu/HuffPost Cold plunging isn’t safe for everyone — and also isn’t the all-in-one wellness trend that many say it is. One scroll through social media lately and you may stumble on videos of fitness influencers or celebrities dunking themselves in cold water in the name of health. Say hello to the world of cold […]
The TikTok Trend That Dentists Are Begging People To Stop Doing At Home
Ittipol Nampochai / EyeEm via Getty Images Teeth scaling, also known as dental scaling, takes things to the next level in terms of tackling plaque buildup. It’s an in-office dental procedure that uses sharp instruments (which are best used by professionals) and careful attention to detail to remove plaque, as seen here (beware, it’s not […]
These Comforting Illustrations Are The Perfect Balm For Overwhelmed Moms
Motherhood is full of conflicting emotions. It can be beautiful and joyful and fun, but it can also be demanding and confusing and overwhelming at the same time. In artist and poet Azalia Suhaimi’s illustrations, the Malaysia-based mother of two offers comforting reminders to parents navigating these ups and downs. Many of her illustrations, which […]
COVID-19 Tied to Doubled Risk of Endocarditis in Substance Use Disorder Patients
Patients with cocaine or opioid use disorder (OUD) had a higher risk of endocarditis if they also contracted COVID-19, a retrospective study showed. COVID-19 infection was associated with an increased risk of newly diagnosed cases of endocarditis among patients with opioid use disorder (HR 2.23, 95% CI 1.92-2.60) and with cocaine use disorder (HR 2.24, […]
How plants protect themselves from oxidative stress during iron uptake — and why this is also important for humans: Biology, chemistry and medicine: Interdisciplinary publication in Plant Physiology
Iron is a critical micronutrient for the survival of plants and humans, yet too much iron can also be toxic. An interdisciplinary research team from Heinrich Heine University Düsseldorf (HHU) has discovered that the protein PATELLIN2 is not only involved in regulating iron levels in plants. PATELLIN2 is one of a group of proteins that […]
7 Holiday Tasks That Are Secretly Depleting You
As merry as it may be, the holiday season can also be synonymous with stress. Between spending lots of money on gifts, living up to the (probably very high) expectations in your head and making time for all of the holiday events throughout the month, it’s an overwhelming season for many people. But you’re definitely […]
Kids Exposed to Smoke In Utero Had Better Lung Function If Moms Popped Vitamin C
Mothers who smoked cigarettes during pregnancy, but also took vitamin C supplements, had children with improved airway function and lower risk of wheeze later on, according to a follow-up study of a randomized trial. At 5 years, kids born to mothers who smoked and took daily vitamin C during pregnancy had 17.2% higher average forced […]