Skin Test Detects Parkinson’s and Other Synucleinopathies
Skin biopsies detected phosphorylated alpha-synuclein in a high proportion of people with Parkinson’s disease and other synucleinopathies. Finding a reliable diagnostic biomarker for synucleinopathies is an urgent unmet need. Further research is needed in other clinical populations to validate these findings. Skin biopsies detected cutaneous phosphorylated alpha-synuclein (p-syn) in a high proportion of people who […]
Parkinson’s Biomarker Shows High Accuracy
An alpha-synuclein seed amplification assay (SAA) accurately detected Parkinson’s disease in cerebrospinal fluid (CSF) and identified people with early, non-motor symptoms prior to diagnosis, cross-sectional data from the Parkinson’s Progression Markers Initiative (PPMI) showed. Sensitivity for Parkinson’s disease overall was 87.7% and specificity for healthy controls was 96.3%, reported Andrew Siderowf, MD, of the University […]