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FDA Approves Antibiotic Combination for Complicated UTIs

The FDA approved the combination of cefepime and enmetazobactam (Exblifep) for the treatment of adult patients with complicated urinary tract infections, including pyelonephritis. The agency’s decision was based on data from the phase III ALLIUM trial in which the β-lactam/β-lactamase inhibitor combination demonstrated superiority over piperacillin/tazobactam. Clinical efficacy was shown for Pseudomonas aeruginosa and among […]

Vitamin C Flops for Severe COVID-19

Intravenous vitamin C did little to increase days free of organ support in adult patients hospitalized with COVID-19, two harmonized clinical trials known as LOVIT-COVID and REMAP-CAP found. Among critically ill patients given vitamin C, the median number of organ-support free days was 7 versus 10 in the control group, with an adjusted OR of […]

Two probiotics identified as promising hypertension treatments

An estimated 40% of the global adult population have high blood pressure, or hypertension, which puts people at risk of cardiovascular disease and other dangerous health conditions. Recent studies suggest that probiotics may offer a protective effect, but researchers have a limited understanding of why shaping the gut microbiota can regulate blood pressure. A study […]

Nutrients drive cellular reprogramming in the intestine

Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation — where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells. Until now, […]

This 1 Habit May Help Reduce The Risk Of Dementia In Older Adults

Hinterhaus Productions via Getty Images A new study found that people who took adult education classes have a lower risk of developing dementia. There are certain habits, like exercising and eating nutritious foods, that are synonymous with healthy aging. A new, large-scale study highlights another method that middle-aged and older adults should also add to […]

Earlier Detection of Cardiac Dysfunction Possible for Young Adult Cancer Survivors

Subclinical diastolic dysfunction may be detected among adult survivors of childhood cancer before left ventricular ejection fraction (LVEF) becomes abnormally low, according to longitudinal echocardiographic data. Among participants in the St. Jude Lifetime Cohort Study (SJLIFE) diagnosed with cancer at a median age of 8 years, the proportion of diastolic dysfunction was approximately 15% when […]

FDA Approves First Oral Antiviral Drug for COVID-19

The FDA has granted full approval to nirmatrelvir-ritonavir (Paxlovid) for treating adult outpatients with mild to moderate COVID-19 who are at risk for severe disease, the agency announced on Thursday. “Today’s approval demonstrates that Paxlovid has met the agency’s rigorous standards for safety and effectiveness, and that it remains an important treatment option for people […]

First Treatment Approved for Rare Genetic Neurologic Disorder

The FDA approved trofinetide (Daybue), the first drug to treat adult and pediatric patients age 2 and older with Rett syndrome, drugmaker Acadia Pharmaceuticals announced Friday. “Now, for the first time after decades of clinical research, healthcare providers finally have a treatment option to address a range of core behavioral, communication, and physical symptoms for […]

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