After Lariat LAA Ligater Disappoints in aMAZE, is a Path Ahead Still Possible?
Adjunctive left atrial appendage (LAA) ligation failed to increase the efficacy of catheter pulmonary vein isolation (PVI) in the aMAZE trial, though it appeared safe enough for further clinical investigation. In a population of people with nonparoxysmal atrial fibrillation (Afib), LAA ligation plus PVI was associated with no better primary effectiveness by 12 months — […]
Antidepressant Maintenance No Help for Bipolar I Depressive Episode
Continuing adjunctive antidepressant treatment for up to a year following remission of an acute depressive episode in patients with bipolar I disorder showed no significant benefit for preventing relapse, a randomized trial showed. At 52 weeks, 31% of patients treated with maintenance escitalopram (Lexapro) or bupropion XL (Wellbutrin XL) for that duration of time experienced […]
Add-On Vraylar Tied to Easing of Recurrent Depressive Symptoms
NEW ORLEANS — Adjunctive cariprazine (Vraylar) was linked with a reduction in depressive symptoms for patients with major depressive disorder (MDD), who had an inadequate response to current therapy, according to a phase III study. When added to a first-line antidepressant, 1.5 mg of once-daily cariprazine resulted in significantly greater average reductions in Montgomery-Åsberg Depression […]