Escalated ADT Falls Short in Men With High-Risk Features After Prostatectomy
SAN FRANCISCO — Add-on hormone therapy plus an antiandrogen to salvage radiation and androgen deprivation therapy (ADT) did not boost survival outcomes in high-risk prostate cancer. In the FORMULA-509 trial, the addition of 6 months of abiraterone acetate (Zytiga) and apalutamide (Erleada) to salvage radiation (RT) and 6 months of ADT with a GnRH agonist […]
Dupilumab May Help in Tough-to-Treat Chronic Spontaneous Urticaria
PHOENIX — Patients who received add-on dupilumab (Dupixent) treatment for chronic spontaneous urticaria (CSU) had reduced symptoms and experienced less itchiness, a phase III trial found. In the 6-month study, participants (adults, adolescents, and children) treated with dupilumab on top of their usual H1-antihistamine (H1-AH) experienced a 4.2-point greater mean reduction in their Itch Severity […]
Paired Anti-Obesity Drugs May Help Teens Shed More Weight After Metabolic Surgery
An add-on oral anti-obesity regimen may bolster bariatric surgery-induced weight loss in teens, a researcher reported. In a pilot study of 10 patients, adolescents who were placed on standard of care plus phentermine (Lomaira, Adipex-P) and topiramate (Trokendi XR, Qudexy XR, and Topamax) saw an average 4.3-point drop in BMI after 12 weeks compared with […]