Immune Checkpoint Inhibitor-Chemo Combo Boosts OS in Advanced Endometrial Cancer
SAN DIEGO — The addition of an immune checkpoint inhibitor (ICI) to chemotherapy up front improved overall survival (OS) in patients with advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status, according to two trials. In the phase III RUBY Part 1, patients treated with dostarlimab (Jemperli) and chemotherapy had a median OS […]
Add-On Clarithromycin Pans Out in Community-Acquired Pneumonia Trial
In a phase III trial, the addition of oral clarithromycin to beta-lactam antibiotic treatment improved the clinical response of people with community-acquired pneumonia who had systemic inflammatory response syndrome, findings that support existing guidelines. In the study, the proportion of patients meeting the primary composite endpoint after 72 hours of treatment — fulfilling criteria for […]
Main regulator for the body`s ‘oven’ discovered
Brown fat cells convert energy into heat — a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area “Life & Health” at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to […]
New Data in NSCLC Bolster Support for Perioperative Immunotherapy
CHICAGO — A randomized trial testing the addition of perioperative pembrolizumab (Keytruda) to chemotherapy in operable non-small cell lung cancer (NSCLC) hit one of its two primary endpoints in an interim analysis, with a favorable trend for the other. All patients in the study received cisplatin-based neoadjuvant chemotherapy, and at 2 years, the event-free survival […]
Sotatercept, Fixed-Dose Combo Therapy on the Right Path for PAH
NEW ORLEANS — The limited clinical evidence thus far supports investigational compounds for addition to or simplification of existing frontline therapies for pulmonary arterial hypertension (PAH), according to two trials presented here at the American College of Cardiology (ACC) annual meeting. The activin signaling inhibitor biologic sotatercept showed promise as an add-on to usual treatment […]
ADVOR Backs Add-On Acetazolamide for Cutting Congestion in Decompensated HF
BARCELONA — The addition of IV acetazolamide to loop diuretic therapy led to a greater incidence of successful early decongestion in patients with acute decompensated heart failure (HF), according to the ADVOR trial. The primary outcome of successful decongestion within 3 days after randomization was 42.2% with acetazolamide versus 30.5% with placebo (P<0.001), reported Wilfried […]
These Inclusive Bandages Match A Variety Of Skin Tones — And You Can Buy Them Online
BioSwiss Truetone skin tone adhesive bandages In addition to BioSwiss’ other bandage offerings, which come in a ton of different shapes and designs, you can also get the brand’s Truetone bandages. Created for a range of skin tones, these bandages come in four colors: dark brown, brown, olive and beige. Each box contains 32 bandages […]
Add-on Pembrolizumab Tied to Good QoL in Women With Advanced Cervical Cancer
PHOENIX — The addition of pembrolizumab (Keytruda) to chemotherapy, with or without bevacizumab (Avastin), in women with persistent, recurrent, or metastatic cervical cancer was linked with better quality of life (QoL), a researcher reported. Patient-reported outcomes (PRO) from the KEYNOTE-826 trial showed that changes from baseline in QLQ-C30 global health status (GHS)/QoL scores — a […]
Novel Blood-Based Test Could Bolster MRI-Based Prostate Cancer Screening
Addition of a novel blood test to MRI-targeted biopsy in prostate cancer screening decreased overdetection while maintaining the ability to detect clinically significant cancer, Swedish researchers reported. They found that use of the test — called Stockholm3 — in a screening setting where MRI and targeted biopsies were used, performed at least as well as […]