Shaking less salt on your food at the table could reduce heart disease risk: Researchers found a link between a lower frequency of dietary salt and a reduced CVD risk
Adding additional salt to foods at a lower frequency is associated with a reduced risk of heart disease, heart failure and ischemic heart disease, according to a new study published today in the Journal of the American College of Cardiology. Even among those following a DASH-style diet, behavioral interventions to lessen salt consumption could further […]
Twelve-Month Data Back Pegloticase-Methotrexate Gout Combo
PHILADELPHIA — Previous findings that adding methotrexate to pegloticase (Krystexxa) in patients with gout was more effective than pegloticase alone have now been extended to a full year of treatment. At month 12 in the randomized, 152-patient MIRROR RCT trial, 60% of patients receiving the combination had serum urate levels below the target of 6 […]
PCI vs CABG: Does Age Inform Choice for Left Main Coronary Artery Disease?
BOSTON — Adding fuel to the controversy of revascularization for left main disease, patients had better survival after coronary artery bypass grafting (CABG) surgery than percutaneous coronary intervention (PCI) in an all-comers nationwide registry study. The incidence of all-cause mortality stayed greater up to 7 years after PCI versus CABG (adjusted HR 1.59, 95% CI […]
Triplet in First-Line Kidney Cancer Thwarts Disease Progression
PARIS — Adding the tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx) to dual immune checkpoint inhibition improved progression-free survival (PFS) in patients with advanced renal cell carcinoma (RCC), the phase III COSMIC-313 trial found. Among 550 patients with untreated intermediate- or poor-risk disease, those treated with the triplet therapy had a median PFS that was not […]
10-Year Follow-Up Confirms Benefit of Chemoradiotherapy in MIBC Patients
Long-term results confirmed that the benefit of adding chemotherapy to radiotherapy was maintained in patients with muscle-invasive bladder cancer (MIBC) in a follow-up to the phase III randomized BC2001 trial. Over a median follow-up of about 10 years, locoregional control was significantly improved by adding 5-fluorouracil and mitomycin C to radiotherapy, with a 5-year recurrence-free […]
Long term high-fat diet expands waistline and shrinks brain
New research shows that fatty foods may not only be adding to your waistline but also playing havoc with your brain. An international study led by UniSA neuroscientists Professor Xin-Fu Zhou and Associate Professor Larisa Bobrovskaya has established a clear link between mice fed a high-fat diet for 30 weeks, resulting in diabetes, and a […]
Did Monkeypox Go Airborne? – MedicineNet Health News
Latest Infectious Disease News WEDNESDAY, June 8, 2022 After adding, and then deleting, a recommendation that U.S. travelers wear masks to protect themselves from monkeypox, the U.S. Centers for Disease Control and Prevention still says that those traveling to countries where the disease is spreading and “other people who may be in close contact with […]
Opioid Use Disorder Training in Med School Improves Awareness of Patient Needs
NEW ORLEANS — Adding opioid use disorder (OUD) training to the third-year medical school curriculum improved students’ understanding on how to manage these patients, according to a study presented at the American Psychiatric Association annual meeting. Third-year students’ knowledge of OUD treatments significantly increased from a pre-training assessment (mean score 18.34/23) to a post-training assessment […]
Consolidation Intensification Fails in High-Risk Metastatic Ewing Sarcoma
Adding high-dose treosulfan and melphalan as further consolidation therapy for high-risk metastatic Ewing sarcoma failed to improve survival outcomes, a randomized phase III study showed. In an intention-to-treat population of 109 patients receiving standard induction and consolidation therapy, no significant difference was seen in event-free survival (EFS) between a group that also received high-dose treosulfan-melphalan […]
Another China-Developed PD-1 Inhibitor Makes Its Case in NSCLC
Adding the investigational PD-1 checkpoint inhibitor toripalimab to chemotherapy in first-line significantly improved progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without EGFR/ALK mutations, according to results from a study conducted in China. Median PFS improved from 5.6 months with chemotherapy alone to 8.4 months with the toripalimab-based combination (HR 0.49, 95% […]