No Improved Outcomes for HF Patients With Sleep Apnea Using ASV Breathing Devices
Breathing machines with adaptive servo-ventilation (ASV) did not improve survival or other clinical outcomes in patients with heart failure (HF) and reduced ejection fraction and sleep-disordered breathing, the phase III ADVENT-HF trial found. Investigators found no difference between patients randomized to standard care plus bilevel positive airway pressure (BiPAP) device therapy with ASV and those […]
MR-Guided Adaptive SBRT Tied to Reduced Side Effects in Prostate Cancer
Magnetic resonance (MR)‐guided adaptive stereotactic body radiotherapy (SBRT) for prostate cancer was associated with significantly lower rates of acute genitourinary and gastrointestinal toxicities compared with CT-guided non-adaptive SBRT, according to a systematic review and meta-analysis. Across 29 prospective studies involving over 2,500 patients, the risk of short‐term genitourinary side effects was reduced by 44% with […]
Chemo-Free Approach Works in Subset of Patients With HER2+ Early Breast Cancer
CHICAGO — An “adaptive response” treatment strategy identified a subset of patients with HER2-positive early breast cancer who benefited from a chemotherapy-free treatment plan, according to the phase II PHERGain trial. The strategy is based on evaluating an early response to a dual HER2 blockade with trastuzumab (Herceptin) and pertuzumab (Perjeta) with 18F-FDG PET imaging […]
New research provides clues to developing better intranasal vaccines for COVID-19 and flu
While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear. New research published this week in mBio,an open-access journal of the American Society for Microbiology, explores the role of nasal bacteria and […]