Midlife Cognition Linked With Moderate and Vigorous Physical Activity
Moderate and vigorous physical activity was linked with midlife cognition, a U.K. study showed. Among nearly 4,500 people born in 1970, time spent performing moderate and vigorous physical activity was associated with higher verbal memory and executive function scores relative to time spent sleeping, being sedentary, or engaging in light activity, according to John Mitchell, […]
Adagrasib Shows Anti-Tumor Activity in Heavily Pretreated KRAS-Mutant CRC
Adagrasib (Krazati) demonstrated antitumor activity in heavily pretreated patients with KRAS G12C-mutated, metastatic colorectal cancer (CRC), according to phase I/II study results. Monotherapy with the oral KRAS inhibitor led to responses in 19% (95% CI 8-33) of 43 evaluable patients with CRC, with a median duration of response of 4.3 months (95% CI 2.3-8.3) and […]
Early life experiences can have long-lasting impact on genes
Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers. In the study published in Nature Aging, the scientists report that gene expression ‘memory’ can persist across the lifespan, and may present a novel target for improving […]
IBD and Preterm Birth Risk; Leprosy Bacteria Promote Liver Growth; COVID and IBD
Histological inflammation and clinical disease activity in inflammatory bowel disease (IBD) were risk factors for preterm birth, especially in the case of ulcerative colitis. (eClinicalMedicine) Leprosy-causing bacteria (Mycobacterium leprae) promoted growth in healthy liver tissue in armadillos and may be able to help renew aging or injured livers. (Cell Reports Medicine) For older IBD patients […]
Pattern of gene activity for ADHD
Researchers at the National Institutes of Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), part of the NIH, found that individuals diagnosed with ADHD had differences in genes that code […]
Activity ‘snacks’ following meals may help maintain muscle mass
Interrupting prolonged sitting with periodic activity “snacks” may help maintain muscle mass and quality, according to a new study by researchers at the University of Toronto. Daniel Moore, an associate professor of muscle physiology at the Faculty of Kinesiology & Physical Eduction (KPE) who led the study, found that short bouts of activity, such as […]
Deep brain stimulation shows promise against binge eating disorder: Pilot study finds that implanted brain-stimulating device dramatically reduced bingeing episodes and helped patients lose weight
A small device that detects food craving-related brain activity in a key brain region, and responds by electrically stimulating that region, has shown promise in a pilot clinical trial in two patients with loss-of-control binge eating disorder (BED), according to researchers at the Perelman School of Medicine at the University of Pennsylvania. The trial, described […]
Spiral wave teleportation theory offers new path to defibrillate hearts, terminate arrhythmias
A spiral wave of electrical activity in the heart can cause catastrophic consequences. One spiral wave creates tachycardia — a heart rate that’s too fast — and multiple spirals cause a state of disorganized contraction known as fibrillation. Researchers from the Georgia Institute of Technology offer a new method to disrupt spiral waves that uses […]
Breast Cancer Survivors Who Work Out See Heart Benefits
Physical activity among long-term breast cancer survivors was associated with better global longitudinal strain (GLS), though not left ventricular ejection fraction (LVEF), data from a cohort study found. Compared with inactive survivors, moderately active breast cancer survivors had a 35% lower risk of abnormal GLS (relative risk [RR] 0.65, 95% CI 0.45-0.94) while active survivors […]
Novel Drug Cuts Proteinuria in APOL1-Mediated Kidney Disease
An investigative treatment targeting APOL1 activity significantly improved proteinuria APOL1-mediated kidney disease (AMKD), a proof-of-concept phase IIa study found. In a single-arm, open-label study, treatment with oral VX-147 — a small molecule acting as an APOL1 function inhibitor — significantly reduced urine protein to creatinine ratio (UPCR) by 47.6% (95% CI -60 to -31.3%) by […]