FDA OKs Nitisinone for Ultra-Rare Black Urine Disease
The FDA approved nitisinone (Harliku) for the reduction of urine homogentisic acid (HGA) in adults with alkaptonuria, Cycle Pharmaceuticals announced on Thursday. Alkaptonuria is an ultra-rare hereditary disorder of tyrosine and phenylalanine catabolism, and is commonly known as black urine disease due to the noticeable buildup of HGA. A slow-progressing disease, alkaptonuria can cause tissue […]
Expanded Label Officially Makes Bempedoic Acid a CVD Prevention Medication
The FDA approved label expansions for bempedoic acid (Nexletol) and bempedoic acid/ezetimibe (Nexlizet) so they can be used more broadly as cardiovascular prevention drugs, Esperion announced Friday. Based on the CLEAR Outcomes trial, the two adenosine triphosphate (ATP) citrate lyase inhibitor drugs are now indicated for adults with either established atherosclerotic cardiovascular disease (CVD) or […]
Want To Avoid Painful Kidney Stones? These Foods Can Help.
Getty Images The citric acid found in citrus helps to prevent crystallization in the kidney. Having a kidney stone is considered one of the most painful experiences you can have, even worse than childbirth. While the stones may be physically tiny, often measured in millimeters, they can feel like tiny little mines exploding as the […]
Do You Have Peeing Issues? These Foods And Drinks May Be To Blame.
Ekspansio via Getty Images The acid in citrus can exacerbate bladder symptoms. You’re likely familiar with foods that aren’t good for your heart. But when it comes to your bladder, it’s possible that you haven’t considered the correlation between diet and peeing. Unless you’ve had a urinary tract infection, suffered from a leaky bladder, or […]
Do You Have Peeing Issues? These Foods And Drinks May Be To Blame.
Ekspansio via Getty Images The acid in citrus can exacerbate bladder symptoms. You’re likely familiar with foods that aren’t good for your heart. But when it comes to your bladder, it’s possible that you haven’t considered the correlation between diet and peeing. Unless you’ve had a urinary tract infection, suffered from a leaky bladder, or […]
Nutrient found in beef and dairy improves immune response to cancer
Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study by researchers from the University of Chicago. The research, published this week in Nature, also […]
Eosinophilic Esophagitis Risk Linked to Medications in Pregnancy, Infancy
Antibiotic and acid suppressant exposure during the perinatal period was linked to the development of eosinophilic esophagitis (EoE) later in life, a Danish cohort study found. Infants with any antibiotic use had a 40% greater risk of developing EoE later in childhood compared to matched controls without such exposure (adjusted OR 1.4, 95% CI 1.1-1.7), […]
Do You Have Peeing Issues? These Foods And Drinks May Be To Blame.
Ekspansio via Getty Images The acid in citrus can exacerbate bladder symptoms. You’re likely familiar with foods that aren’t good for your heart. But when it comes to your bladder, it’s possible that you haven’t considered the correlation between diet and peeing. Unless you’ve had a urinary tract infection, suffered from a leaky bladder, or […]
Bempedoic Acid Gets ‘Huge’ Win for Primary Prevention in the Statin-Intolerant
SAN DIEGO — Bempedoic acid (Nexletol) prevented cardiovascular events in high-risk, statin-intolerant patients who had not yet had an event, a subgroup analysis from the CLEAR Outcomes trial confirmed. In these patients, bempedoic acid was associated with a large decrease in risk of major adverse cardiovascular events (MACE) compared with placebo over a median 39.9 […]
Ocaliva for NASH Gets Thumbs Down From FDA Advisors
A panel of FDA’s outside experts said obeticholic acid (Ocaliva) does not have a favorable risk-benefit profile for treating nonalcoholic steatohepatitis (NASH) with pre-cirrhotic liver fibrosis, and recommended against accelerated approval of the drug. On Friday, the Gastrointestinal Drugs Advisory Committee voted 12-2 (with two abstentions) that the improvements in liver scarring seen in the […]